Solubility of theophylline in water

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August undefined, 2024

WebAug 1, 1994 · The results were treated on the basis of the extended Hildebrand solubility approach considering interaction terms. An equation has been obtained for predicting the … WebJun 16, 2024 · From the observation, the Theophylline is more soluble in sodium salicylate hydrotrope than other three hydrotropes. Since it is a water soluble molecular structure …

Dimensional changes, gel layer evolution and drug release studies …

WebOct 9, 2013 · In this paper, the influence of polymorphs on the transformation water activity that corresponds to the transformation between hydrate and anhydrate of theophylline was investigated. Theophylline is known to exist either as anhydrates or a monohydrate. The transformation water activities of theophylline form II and IV were determined … WebTheophylline (3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ); anhydrous, ≥ 99%, powder; campgrounds in kelowna area

RJPT - New Quantitative Technique for estimation of solubility of ...

WebSolubility: Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in ammonia Sweetman (2002). Ionization Constant: Value: Salt: Conditions: Reference: Comments: pKa: 8.77: monohydrate: 25° O'Neil et al (2001) WebTheobromine solubility was studied in dioxane-water mixtures, a solvent system that was investigated earlier for the solubility of theophylline and caffeine. Solubilities were calculated in these polar systems by a regression method, based on an extension of the Hildebrand-Scatchard equation of regular solution theory. WebThe solubility of theophylline in the resultant products was found to be three to five times higher than that of original theophylline. The solubilities of the products decreased with increasing drying temperature and rotation speed of the atomizer, which was interpreted in terms of the contents of ethylenediamine in the products. first time tampon insertion

Dimensional changes, gel layer evolution and drug release studies …

Table 4 . Solubility of theophylline at different pH values

WebApr 14, 2024 · Purpose Nitrofurantoin is an effective antibacterial drug for the treatment of lower urinary tract infection. However, the anhydrate form can easily transform to the less soluble hydrate form (monohydrate) during dissolution, resulting in a reduction of dissolution rate and oral bioavailability. Therefore, inhibition of phase transformation is … WebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... first time taking suboxoneWebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ... first time tampon user brand

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Solubility of theophylline in water

Extended Hildebrand Solubility Approach: methylxanthines in …

WebTheophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates ... colorless solution. It is soluble in 0.1 M HCl, 0.1 M … WebJul 8, 2024 · Theophylline, a typical representative of active pharmaceutical ingredients, was selected to study the characteristics of experimental and theoretical solubility measured …

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WebIncreasing the oral bioavailability of poorly water-soluble carbamazepine using immediate-release pellets supported on SBA-15 mesoporous silica Zhouhua Wang,1,2 Bao Chen,1 Guilan Quan,1 Feng Li,1 Qiaoli Wu,1 Linghui Dian,1 Yixuan Dong,1 Ge Li,2 Chuanbin Wu1,21School of Pharmaceutical Sciences, 2Research and Development Center of … WebAug 1, 2024 · The equilibrium solubility of caffeine and theophylline were determined in {methanol + water} binary mixtures at 298.15 K by means of the shaken flask method and …

WebThe observed dissolution rate of theophylline monohydrate under various conditions agreed well with predictions based on the Extended Simultaneous Chemical Reaction and … WebTheophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is …

WebJun 24, 2024 · This study aimed to assess the use of semi-solid extrusion-based 3D printing for the preparation of tailored doses of theophylline in the form of a chewable dosage form ... respectively. However, more importantly, GBP is freely soluble in water, whereas TPH is only slightly soluble in water [43,44], giving rise to a higher ... WebHowever, theophylline is only sparingly soluble in water and alcohol. The solubility of theophylline in water is 5.5 mg/mL, whereas in methanol and ethanol is 0.699 mg/mL and …

WebC s is the solubility of theophylline and k is the pH of the theophylline solution. The results are shown in Table 4.From the table,it is seen that, the solubility of theophylline increases …

WebMar 1, 1983 · The solubilities of theophylline and theophylline hydrate as a function of temperature are determined in the temperature range 288–365K. The solubility as a … campgrounds in kentucky on a lakeWebDimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility K Avgoustakis 2007, International Journal of Pharmaceutics campgrounds in kansas city ksWebAug 24, 2024 · Solubility is a very important property of drugs involved in purification processes and the different pharmaceutical dosage form design stages. Otherwise, … campgrounds in kentucky open year roundWebJun 27, 2024 · The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was … campgrounds in kettle moraine wi greenbush first time talking in yearsWebDec 7, 2024 · Theophylline salts — Several so-called "salts” of theophylline had been developed as attempts to increase water solubility (8 mg/mL at 25ºC) and improve absorption. While salts of theophylline may be formed with a base at high pH, theophylline is only slightly ionized at physiological pH (pK a = 8.8). campgrounds in kern riverWebIn the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled … campgrounds in kitsap county washington