Web16 Jan 1998 · We report that XRCC4 is an efficient in vitro substrate of DNA-PK and another unidentified serine/ threonine protein kinase(s). Both DNA-PK dependent and independent phosphorylation of XRCC4 in vitro occurs only on serine and threonine residues within the COOH-terminal 130 amino acids, a region of the molecule that is not absolutely required … WebOur aim was to design novel mTOR inhibitors which could bind at both the allosteric and the kinase site. The FRB domain is present in both the mTORC1 and mTORC2 protein complexes. We have employed e-pharmacophore-guided fragment-based design to develop novel mTOR inhibitors.
Mycobacterium tuberculosis serine/threonine protein kinases: …
Web30 Aug 1996 · Nck is an adaptor protein composed of a single SH2 domain and three SH3 domains. Upon growth factor stimulation, Nck is recruited to receptor tyrosine kinases via its SH2 domain, probably initiating one or more signaling cascades. In this report, we show that Nck is bound in living cells to the serine-threonine kinase Pak1. WebNon Receptor Protein Tyrosine Phosphatase 2. TCPTP is a negative regulator of the JAK/STAT pathway and, interestingly, JAK1 activating mutations are found in patients where PTPN2 is deleted, further potentiating the JAK/STAT pathway. From: Progress in Molecular Biology and Translational Science, 2012. callyoubymyname完整版观看
9317 PDFs Review articles in TOR SERINE-THREONINE KINASES
Web23 Apr 2014 · In mammals, its orthologue is called mammalian TOR (mTOR). mTOR is a serine/threonine kinase that converges different extracellular stimuli, such as nutrients … WebThe serine/threonine-specific protein kinase Akt (protein kinase B), when phosphorylated by phosphotidylinositol-3-kinase, is a key mediator of tolerance. 113 This protection appears … WebA serine threonine kinase that controls a wide range of growth-related cellular processes. The protein is referred to as the target of RAPAMYCIN due to the discovery that … callum fealy