WebOrbitally shaken bioreactors (OSBs) utilize the same hydrodynamic principles that define the success of smaller-scale cultur … Increasing the cultivation volume from small to large … WebAug 11, 2024 · Orbitally shaken bioreactors (OSRs) support the suspension cultivation of animal cells at volumetric scales up to 200 L and are a potential alternative to stirred-tank bioreactors (STRs) due to their rapid and homogeneous mixing …

Scalable Production of AAV Vectors in Orbitally Shaken …

WebJun 15, 2012 · The volumetric power input of the 200 L and 2000 L orbitally shaken bioreactors (Kühner AG, Birsfelden, Switzerland) was measured applying a slightly modified temperature method. The temperature method is based on the fact that the volume specific heat energy per time produced by the friction of the liquid on the walls of the bioreactor is ... WebOrbitally shaken cylindrical bioreactors [OrbShake bioreactors (OSRs)] without an impeller or sparger are increasingly being used for the suspension cultivation of mammalian cells. Among small volume OSRs, 50-mL tubes with a ventilated cap (OSR50), originally derived from standard laboratory centrifuge tubes with a conical bottom, have found ... tschibo.at online shop

Mixing Performance Analysis of Orbitally Shaken Bioreactors

Orbitally shaken bioreactors are widely used for small-scale screening and process optimization. Complex mechanical and electronic parts such as the shaker drive, the power train, and the control unit are integrated in the shaker and, therefore, separated from the reactor vessel. See more The well-defined and homogeneous liquid distribution during shaking is a key benefit of orbitally shaken single-use reactors. Reproducible flow … See more The applicability of orbitally shaken single-use reactors for aerobic bioprocesses highly depends on their potential to deliver a sufficient amount of oxygen to the cells. The first quantitative characterization of the oxygen transfer in … See more The first detailed characterization of the mixing performance in cylindrical orbitally shaken bioreactors with volumes ranging from 2 to 1,500 L was reported by Tissot et al. [29]. A calorimetric method was used to determine mixing … See more WebAn Erlenmeyer flask, also known as a conical flask (British English) or a titration flask, is a type of laboratory flask which features a flat bottom, a conical body, and a cylindrical neck. It is named after the German chemist … WebJan 15, 2014 · At laboratory scale, cells are usually grown in low shear devices, with orbitally shaken bioreactors (OSRs) being largely employed in the early stages of bioprocess … tschick andre langin