Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination. WebCullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination. [1] [2]
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WebDec 23, 2024 · cullin-RING 连接酶 (CRL) 是 E3 泛素连接酶的主要家族。 酵母中的原型 CRL，称为 SCF 酶，使用单一 E2 酶 Cdc34 来构建降解所需的多泛素链。 相比之下，六种不同的人类 E2 和 E3 酶活性，包括 Cdc34 直向同源物 UBE2R1 和 UBE2R2，似乎在体外介导 SCF 催化的底物多泛素化。 这些酶的组合相互作用提出了关于人类细胞中 SCF 的遗 … WebApr 13, 2024 · 讲座题目：SAG/RBX2-Cullin RING 泛素E3连接酶: 从抗肿瘤靶点鉴定到药物研发时间：2024年4月14日（星期五）上午9：30地点：厦门 ... black and white eiffel tower canvas
Function and regulation of cullin–RING ubiquitin ligases
WebThe cullin-RING ligases (CRLs) are a highly polymorphic E3 collection composed of a cullin backbone onto which binds carriers of activated Ub and a diverse assortment of adaptors that recruit appropriate substrates for ubiquitylation. Here, we review our current understanding of the organization and structure of CRLs in plants and their ... Webe3泛素连接酶根据其结构特征和作用机制，可以被分为三个家族：ring e3s、hect e3s和rbr e3s。 E3连接酶结合E2 Ub复合物和底物后，RING E3s催化泛素从E2直接转移到底物的 … WebHome; Products. Featured Collections. Recombinant Rabbit Monoclonal Antibodies; IHC/Pathology Antibodies; KO Validated Antibodies; Antibodies. Primary Antibodies gaetz father