Cisplatin vs carboplatin ototoxicity

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August undefined, 2024

WebSep 21, 2016 · Cisplatin is the most ototoxic drug known, and a mean ototoxicity incidence of 33% has been reported when patients received a single dose of 50 mg/m 2 … WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin crosses into the cochlea, which often results in permanent sensorineural cisplatin-induced hearing loss (CIHL).

Special Issue "Metal-Based Complexes in Cancer Treatment"

WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. WebCis-diamminedichloroplatinum (cisplatin), a divalent platinum compound and cell-cycle nonspecific chemotherapeutic agent, produces a permanent high-frequency … reading rainbow logopedia

Carboplatin - LiverTox - NCBI Bookshelf - National Center for ...

WebFeb 26, 2024 · The cisplatin ototoxicity occurs between 23% and 50% in adults and up to 60% in children [4,6]. However, some studies have reported elevated hearing thresholds in up to 100% of cisplatin-treated cancer patients [7,8], while it is estimated to be 63% with aminoglycosides and 6-7% with furosemide [9]. Web18/40 (45%) evidence of ototoxicity at audiometry. To date we have seen no neuro- or ototoxicity with carboplatin and 1/40 (2.5%) have developed WHO grade I renal toxicity. Myelo- ... Key words: Ovarian cancer; cisplatin, carboplatin, toxicity, efficacy, randomized study. Cisplatin is the most active drug in ovarian cancer ... WebJan 1, 2024 · Regarding the frequency of ototoxicity of antineoplastic drugs and the dose required to trigger these effects, an important heterogeneity was observed. The frequency of ototoxicity caused by cisplatin ranged from 45% to 83.3% and, when used in combination with carboplatin, ranged from 16.6% to 75%. reading rainbow list

Practical Grading System for Evaluating Cisplatin …

Overview of cisplatin-induced neurotoxicity and ototoxicity

WebFeb 1, 1991 · The main known side effects of cisplatin are a high emetogenic potential and various organotoxic effects. Cisplatin can be nephrotoxic (8), ototoxic (9) and neurotoxic (especially with peripheral ... WebOct 8, 2010 · Carboplatin, a therapeutic alternative to cisplatin, has been shown to be less ototoxic, with reported toxicity rates of 0–38% [ 4, 10 – 12, 18, 19 ]. Carboplatin is also … reading rainbow louis the fishWebThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. how to support homeless students

"WebMar 31, 2024 · Metal-based complexes contribute a vital part in the available arsenal of cytotoxic agents today. Platinum (II) complexes, specifically targeting genomic DNA (e.g., cisplatin and carboplatin), are widely used in the clinic for the treatment of various cancers. Nearly 50% of cancer patients, who undergo chemotherapy, receive a platinum … " - Cisplatin vs carboplatin ototoxicity

Cisplatin vs carboplatin ototoxicity

Platinum-induced ototoxicity: a review of prevailing ototoxicity ...

WebHowever, we consider that elderly patients with age-related hearing impairment are more likely to suffer from ototoxicity of cisplatin and discontinue scheduled treatment. Therefore, elderly patients who require cisplatin treatment should be carefully managed. ... The EXTREME trial evaluated the effect of cetuximab on cisplatin/carboplatin plus ... WebApr 26, 2024 · Tumors treated by cisplatin include adults with head and neck cancer and testicular, ovarian and lung cancers. Cisplatin is a key chemotherapeutic agent used to …

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WebCisplatin is used in the treatment of several childhood malignancies. Improvement in long -term survival has made the monitoring of long-term side effects more important. Nephrotoxicity and high frequency hearing loss are the most notable adverse effects of cisplatin in children. Brock et. al (1991) WebChemotherapeutic (antineoplastic) drugs, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. Hearing loss can be profound and permanent, occurring immediately after the first dose, or can be delayed until several months after completion of treatment.

WebA Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors: Actual Study Start Date ... [PROs] of ototoxicity) Note: participants in group 1 will not receive AGCT1531 protocol-directed therapy; all other AYA-HEARS patients must be ... WebThe antineoplastic agent's cisplatin and carboplatin are widely used as they are highly effective. Unfortunately, ototoxicity is a frequently encountered side effect of platinum-based chemotherapy. Clinically, patients generally develop a progressive, bilateral, and irreversible sensorineural hearing loss.

WebFinal results indicate that the investigational chemotherapeutic analogs CBDCA (JM-8) and CHIP (JM-9) do not produce the ototoxicity and nephrotoxicity characteristic of cisplatin. Furthermore, these findings demonstrate 195mpt localization in the vestibular labyrinth and confirm previous platinum distribution studies in the organ of Corti and ... WebEfficacy and safety of a cisplatin and paclitaxel (TP) induction regimen followed by chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC)

WebBesides myelosuppression, nephrotoxicity and ototoxicity are dose-limiting for cisplatin, whereas thrombocytopenia is dose-limiting for carboplatin. Cisplatin is extensively bound to plasma proteins and clear pharmacokinetic-PD correlations have been identified for the ultrafiltrable, i.e., unbound fraction of the drug in plasma and toxicity as ...

WebMar 3, 2015 · Key clinical point: Paclitaxel plus carboplatin is noninferior to paclitaxel plus cisplatin for metastatic or recurrent cervical cancer. Major finding: The carboplatin regimen, with a median overall survival of 17.5 months, proved to be noninferior to the cisplatin regimen, which had a median OS of reading rainbow kid book reviewsWebIbero-American Expert Consensus on Squamous Cell Carcinoma of the Head and Neck Treatment in Patients Unable to Receive Cisplatin Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. how to support laid off employeesWebJul 3, 2024 · Cisplatin is a widely used chemotherapeutic agent with a high degree of ototoxicity and an average incidence of over 60% ( Karasawa and Steyger, 2015 ). Ototoxicity depends on several factors, including patient age, cumulative dose of cisplatin, and genetic susceptibility ( Landier, 2016; Lanvers-Kaminsky and Ciarimboli, 2024 ). reading rainbow list of booksWebAug 19, 2007 · Pooling the results of all of these cis vs. carbo studies together, the response rate with cisplatin combinations was higher (30% vs. 24%), and the overall survival … how to support granite countertopWebThe dose-limiting side effect for cisplatin is nephrotoxicity, for carboplatin it is myelosuppression, and for oxaliplatin it is neurotoxicity. Other common side effects … how to support husband who was laid offWebMar 25, 2024 · The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity guidelines. Case series including retrospective medical records review of patients (age > 18) treated … how to support homeless youthWebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. … reading rainbow martha speaks