Cisplatin gsh

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August undefined, 2024

WebThree mechanisms have been proposed for the role of glutathione (GSH) in regulating cisplatin (CDDP) sensitivities that affects its ultimate cell-killing ability: (i) GSH may … WebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers.

The role of GSH in MRP-mediated CDDP transport. De novo

WebEbselen is a seleno-organic compound with documented cytoprotective properties. Little work has been done, however, demonstrating ebselen's cytoprotective prop WebGSH reacts with hydrogen peroxide and organic peroxides, the harmful byproducts of aerobic life. GSH is also essential for maintaining the normal structure of red blood cells.4 In the presence of cisplatin, GSH forms a 2:1 (GSH:platinum) complex … how hot can a geyser get

Reversal of cisplatin chemotherapy resistance by glutathione …

WebAug 8, 2010 · Cisplatin can bind to the thiol group of intracellular glutathione (GSH) and this reaction is considered important for the inactivation of cisplatin . However, Gibson and coworkers recently suggested that binding of cisplatin to GSH is not the most important cellular interaction for inactivation ( 17 ). WebNov 27, 2024 · Cisplatin is the first-line chemotherapy treatment for those patients, however, resistance to this drug is a common and yet not fully understood phenomenon. Aiming to shed new light into this puzzle, we used established normal and malignant lung cell lines displaying different sensitivity towards cisplatin treatment. WebThe therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of … highfield learning academy blackpool

Antioxidants Free Full-Text Decreased Levels of GSH Are …

Intracellular glutathione-depleting polymeric micelles for cisplatin …

WebAlthough cisplatin (cisPt) is one of the most often used cytotoxic drugs in the treatment of cancer, its clinical application is associated with nephrotoxicity 掌桥科研一站式科研服务平台 WebMar 13, 2006 · Cisplatin is one of the most widely used chemotherapeutic drugs for treating cancer. Initially, platinum-based therapies are very effective in treating a wide array of cancers; however, recurrence and … how hot can a crock pot getWebApr 25, 2024 · Cisplatin accumulates in the mitochondria of renal epithelial cells during excretion of cisplatin metabolites through renal tubules and further forms a cisplatin–glutathione (GSH) complex, which ... highfield learning login

"WebJul 1, 2013 · GSH concentration was measured with UV-Visible double beam spectrophotometer, using the Ellman’s method. The level of GSH was lowered upon addition of cisplatin to plasma and cytosolic... " - Cisplatin gsh

Cisplatin gsh

Web(GSH) transferase activity of GST P1-1. Instead, GST P1-1 sequesters and inactivates cisplatin with the aid of 2 solvent-accessible cysteines, resulting in protein subunits cross-linking, while maintaining its GSH-conjugation activity. Furthermore, it is well known that GST P1-1 binding to the c-Jun N-terminal kinase (JNK) inhibits JNK phosphory- WebSep 18, 2024 · NCBI Bookshelf

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WebJun 20, 2024 · We propose here a new mechanism of cisplatin resistance mediated by glutathione transferase (GST) P1-1, as a cisplatin-binding protein. Our results show that … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebNov 27, 2024 · It is well established that one of the main factors that promote intracellular cisplatin detoxification is GSH, since it can bind covalently to the drug and prevent it to … WebOxidative stress caused by cisplatin, evidenced by increases in kidney tissues malondialdehyde (MDA) content, cytochrome P450 E1 (CYP2E1), renal 4-hydroxynonenal (4-HNE) levels and decreases of glutathione (GSH) and superoxide dismutase (SOD) contents, was significantly ameliorated by AGBE pretreatment.

WebAug 10, 2024 · Overall, our data suggest that cisplatin treatment could positively select cancer cells which are independent from GSH for the maintenance of redox balance, and thus less sensitive to cisplatin-induced oxidative stress, opening new scenarios for the GSH pathway as a therapeutic target in HGSOC. Keywords: WebDec 15, 2015 · HCT116 colon carcinoma was selected as cancer cell prototypes that overexpress GSH. 49 Cells were incubated for 6 hours with CDDP-containing samples (or controls) in order to mimic the clinically used intravenous (iv) infusion of cisplatin, and then further incubated for 66 hours in fresh media to assess the cytotoxicity profiles over a …

WebMar 20, 2024 · GSH-depleting agents buthionine sulfoximine is a useful agent for inhibition of γ-glutamylcysteine ligase, and it reduced the resistance to cisplatin in malignant glioma (Rocha et al., 2015). However, non-specific GSH depletion can cause irreversible damage in most normal tissues.

WebFeb 17, 2024 · The results showed that levels of glutamine, glutamate, and glutathione (GSH), a key drug resistance mediator synthesized from glutamate, were significantly elevated in A2780cis cells than those in A2780 cells. Furthermore, glutamine starvation decreased the GSH levels and CDDP resistance in A2780cis cells. highfield learning actWebOct 1, 2024 · In brief, the reduction of GSH can rescue the inactivation of cisplatin, increase sensitivity of cancer cells to platinum drugs. As shown in Fig. S1A (Supporting information), CDDP-OH was firstly synthesized through oxidizing cisplatin by H 2 O 2 using the method previously reported [21]. highfield leadership academy vacanciesWebThe widespread damage to the seminiferous epithelium induced by cisplatin administration was less severe in mice simultaneously treated with ghrelin. Furthermore, ghrelin … highfield learning food log inWebHerein, we report that the SLC7A11-AS1 and xCT are involved in cisplatin resistanc … Functional role of the SLC7A11-AS1/xCT axis in the development of gastric cancer cisplatin-resistance by a GSH-dependent mechanism Free Radic Biol Med. 2024 Mar 30;S0891-5849(22) 00129-0. doi ... how hot can a graphics card getWebFeb 12, 2024 · Cisplatin, [Pt (NH 3) 2 Cl 2] (CDDP), is a potent chemotherapeutic agent used for several types of cancer, e.g. carcinoma of the ovary, testicle, head and neck, bones, brain, lymph node, and skin. 1,2 CDDP still represents the elective cytotoxic agent for the treatment of the carcinoma of the ovary, which is the leading cause of death … how hot can a gas stove getWebPubMed Central (PMC) how hot can a gpu runWebJan 15, 2024 · Cisplatin is a chemotherapeutic agent widely used to treat various malignancies, and its application is greatly limited due to its nephrotoxicity, including its onset of acute kidney injury (AKI) [ 1 ]. Undoubtedly, effective drugs to prevent cisplatin-induced AKI (Cis-AKI) in clinical practice are in urgent demand. how hot can a heat pump get